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Jean-Paul Gonzalez

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Jean-Paul Joseph Gonzalez (born August 28, 1947) is a French virologist. He graduated from the Medical School of Bordeaux University (M.D., Internal Medicine) France.

Jean Paul Gonzalez
Jean Paul Gonzalez conducting public health interview in Laos

Research career

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Gonzalez is a virologist[1] whose main fields of research encompass the fundamentals and domains of disease emergence,[2] viral disease and eco-epidemiology (i.e. arbovirology, viral hemorrhagic fevers).[3][4][5][6] He received his PhD in viral ecology in 1984 from the University of Clermont-Ferrand[7] in France. He was recruited by the French Institute of Research for Development, IRD (alias ORSTOM), and he dedicated his career to research, training, and providing expertise for developing countries across the Americas, Africa and Asia. He has led field and laboratory teams of researchers in countries such as Brazil, Central African Republic, Gabon,[8] Laos, Senegal, Sierra-Leone, Thailand, Ukraine and more. He worked as a fellow at the Center for Disease Control and Prevention in Atlanta and Fort Collins, and as a visiting professor at the Yale Arbovirus Research Unit[9] (Yale University, School of Medicine). Gonzalez has been involved in high security laboratory practices and research and, early development of geographical information systems applied to infectious diseases. He and his teams have identified new pathogens for humans and animals, have developed tools and strategies for bio-surveillance, and control and prevention of highly infectious transmitted disease (i.e.: high consequence pathogens[10]). He has developed several scientific concepts and research strategies for health (e.g.: long lasting co-evolution of germs and hosts). He was instrumental to introduce and applied the concept of One Health in low income countries.

Early life

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Gonzalez was born and raised near the town of Saint Georges de Didonne in South-West of France in 1947. His father, Jesus Gonzalez, was a Spanish immigrant, born in Madrid who fled from General Franco’s regime to France during the Spanish Civil War. Jean-Paul's mother, Jeanne Charlotte Rives, was third daughter of a barrel maker from the Blaye vineyard of Bordeaux. She raised their three children (Denis, Denise and Jean-Paul).

Medical learning and research

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Gonzalez graduated from the Medical School of Bordeaux University in 1974. By attending the same school, he also got a Master on Tropical Medicine and Hygiene as well as a Medical Diploma of the French Commercial Navy.

This was followed by a residence in French Guiana at the Hôpital André-Bouron, located on the left bank of the Maroni River on the amazonian forest. Gonzalez was in charge of the adult, pediatric, and geriatric wards, as well of the Acarouany leprosy hospital and, health control over the Maroni River border between French Guiana and Suriname. He returned to Bordeaux and took the position of associate professor of Parasitology and Fundamental Sciences at Bordeaux School of Medicine and as medical attendant at the Children Teaching Hopital (Hôpital des Enfants Malades[11]). He also worked at the Saint-André Teaching Hospital as a biologist.

Gonzalez did his 18 months national duty as a Volunteer at the National Active Service (VSNA) at the Pasteur Institute of Tunis (Tunisia) where he traveled extensively for the Pasteur Institute as a WHO (World Health Organization) expert collecting mosquitoes’ larvae and identifying imago for the surveillance of malaria in Tunisia. There he published several fundamental articles on the Tunisian endemic fauna parasites (fresh water turtles,[12][13] rodents[13] and cockroaches). Gonzalez later spent more than ten years as laboratory chief, and then department head within the Institut Pasteur International Network[14] (RIIP) in Bangui, Central African Republic, and in Dakar.

Jean Paul Gonzalez and team training public health workers for viral hemorrhagic fever preparedness and response

In 1990 he was one of the first foreign doctors to work at the high containment laboratory (BSL4) in Atlanta. There he analyzed all the samples previously collected in Central Africa in search of Viral Hemorrhagic Fever traces including Ebola and Marburg,[15][16] Arenavirus,[17] Hantavirus,[18][19] Crimean Congo Hemorrhagic[20] virus and others. In the late 90s he began working as a professor of Epidemiology and Public Health at the Yale School of Medicine; focusing on arboviruses and hemorrhagic viral fevers including Argentinian, Bolivian, Brazilian,[21] Venezuelan,[22][23] and Dengue fevers[24][25] among others.

Since the early 1980s to date he continues to study, train and give expertise on Viral Hemorrhagic fevers including, among others, a follow up on Ebola fever (alias Ebolavirus Disease)[26][27][28][29][30][31][32] and other high consequence pathogens.[33][34]

From 2008 to 2012 he was appointed as General Director of the International Center of Medical Research of Franceville, Republic of Gabon (CIRMF). Appointed there by the French Ministry of Europe and Foreign Affairs and, then nominated at the direction position by the Gabon President (H.E. Omar Bongo), he intensively participate to the development of innovative field of research of interest for Gabon’ public health, including preparedness and response of high consequent pathogens,[35][36] One Health approach as a tool for public health improvement,[37] co-founded the Central African Network for Sickle Cell Study (REDAC), among other advancements.

In 2012, he joined Metabiota,[38] Inc. as Senior Staff Scientist, where he used his expertise on emerging viral disease,[39] biosafety, biosecurity and bio-surveillance, and trains scientists from low income countries of Africa[40] and Eastern Europe.[41] In 2017 he was appointed at Deputy Director of the Center of Excellence for Animal and Zoonotic Diseases (CEEZAD[42]), Kansas State University (KSU).[43][44] Where his work focuses extensively on zoonosis,[45][46] perpetuating also his engagement on One Health approach (One Health News Letter) and Global Health.

He has published more than 250 peers reviewed (NCBI[47]) scientific papers, books[48] and book chapters.

Jean Paul Gonzalez presenting the Center of Excellence of Emerging Zoonotic and Animal Disease (Kansas State University, Manhattan, KS) at University of Kansas School of Medicine, Lawrence, KS.

References

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  1. ^ "Jean-Paul Gonzalez resume".
  2. ^ Gonzalez JP, Souris M, Valdivia-Granda W (2018). "Global Spread of Hemorrhagic Fever Viruses: Predicting Pandemics". Hemorrhagic Fever Viruses. Methods in Molecular Biology. Vol. 1604. pp. 3–31. doi:10.1007/978-1-4939-6981-4_1. ISBN 978-1-4939-6980-7. PMC 7120037. PMID 28986822.
  3. ^ Gonzalez JP, Saluzzo JF, Hervé JP, Geoffroy B (September 1979). "[Serological survey on the prevalence of arboviruses in man in forest and periforest environments of the region of Lobaye (Central African Republic)]". Bulletin de la Société de Pathologie Exotique et de ses Filiales. 72 (5–6): 416–23. PMID 233526.
  4. ^ Nakgoi K, Nitatpattana N, Wajjwalku W, Pongsopawijit P, Kaewchot S, Yoksan S, Siripolwat V, Souris M, Gonzalez JP (January 2014). "Dengue, Japanese encephalitis and Chikungunya virus antibody prevalence among captive monkey (Macaca nemestrina) colonies of Northern Thailand". American Journal of Primatology. 76 (1): 97–102. CiteSeerX 10.1.1.1007.5947. doi:10.1002/ajp.22213. PMID 24105916. S2CID 30633437.
  5. ^ Marrama L, Spiegel A, Ndiaye K, Sall AA, Gomes E, Diallo M, Thiongane Y, Mathiot C, Gonzalez JP (November 2005). "Domestic transmission of Rift Valley Fever virus in Diawara (Senegal) in 1998". The Southeast Asian Journal of Tropical Medicine and Public Health. 36 (6): 1487–95. PMID 16610651.
  6. ^ Gonzalez JP, Camicas JL, Cornet JP, Wilson ML (November 1998). "Biological and clinical responses of west African sheep to Crimean-Congo haemorrhagic fever virus experimental infection". Research in Virology. 149 (6): 445–55. doi:10.1016/S0923-2516(99)80013-2. PMID 9923021.
  7. ^ "UFR Sciences et Technologies, Université Clermont Auvergne". sciences.univ-bpclermont.fr (in French). Archived from the original on 2018-05-26. Retrieved 2018-05-23.
  8. ^ Clottey, Peter. "Gabon President Bongo Launches Ambitious Development Agenda". VOA. Retrieved 2018-06-29.
  9. ^ "The Yale School of Epidemiology and Public Health". Archived from the original on 2018-07-28. Retrieved 2018-05-25.
  10. ^ Belay ED, Monroe SS (February 2014). "Low-incidence, high-consequence pathogens". Emerging Infectious Diseases. 20 (2): 319–21. doi:10.3201/eid2002.131748. PMC 3901478. PMID 24596949.
  11. ^ "L'hôpital des Enfants". L'hôpital des Enfants (in French). Retrieved 2018-05-23.
  12. ^ Mishra GS, Gonzalez JP (September 1978). "[Parasites of fresh water turtles in Tunisia]". Archives de l'Institut Pasteur de Tunis. 55 (3): 303–26. PMID 756699.
  13. ^ a b Mishra GS, Gonzalez JP (March 1978). "Eimeria gundii n. sp. (Protozoa: Eimeriidae) from Tunisian gundi (Ctenodactylus gundi)". Annales de Parasitologie Humaine et Comparée. 53 (2): 241–3. doi:10.1051/parasite/1978532241. PMID 677725.
  14. ^ "The Institut Pasteur International Network". Institut Pasteur. 2016-08-24. Retrieved 2018-05-23.
  15. ^ Ivanoff B, Duquesnoy P, Languillat G, Saluzzo JF, Georges A, Gonzalez JP, McCormick J (1982). "Haemorrhagic fever in Gabon. I. Incidence of Lassa, Ebola and Marburg viruses in Haut-Ogooué". Transactions of the Royal Society of Tropical Medicine and Hygiene. 76 (6): 719–20. doi:10.1016/0035-9203(82)90089-x. PMID 7164137.
  16. ^ Saluzzo JF, Gonzalez JP, Hervé JP, Georges AJ, Johnson KM (May 1980). "[Preliminary note on the presence of antibodies to Ebola virus in the human population in the eastern part of the Central African Republic]". Bulletin de la Société de Pathologie Exotique et de ses Filiales. 73 (3): 238–41. PMID 7014009.
  17. ^ Georges AJ, Gonzalez JP, Abdul-Wahid S, Saluzzo JF, Meunier DM, McCormick JB (1985). "Antibodies to Lassa and Lassa-like viruses in man and mammals in the Central African Republic". Transactions of the Royal Society of Tropical Medicine and Hygiene. 79 (1): 78–9. doi:10.1016/0035-9203(85)90242-1. PMID 2986324.
  18. ^ Gonzalez JP, McCormick JB, Baudon D, Gautun JP, Meunier DY, Dournon E, Georges AJ (November 1984). "Serological evidence for Hantaan-related virus in Africa". Lancet. 2 (8410): 1036–7. doi:10.1016/s0140-6736(84)91130-9. PMID 6149414. S2CID 38525248.
  19. ^ Coulaud X, Chouaib E, Georges AJ, Rollin P, Gonzalez JP (1987). "First human case of haemorrhagic fever with renal syndrome in the Central African Republic". Transactions of the Royal Society of Tropical Medicine and Hygiene. 81 (4): 686. doi:10.1016/0035-9203(87)90455-x. PMID 2895515.
  20. ^ Georges AJ, Gonzalez JP (1986). "Could Crimea-Congo haemorrhagic fever be a biohazard in the Central African Republic?". Transactions of the Royal Society of Tropical Medicine and Hygiene. 80 (6): 994–5. doi:10.1016/0035-9203(86)90287-7. PMID 3111034.
  21. ^ Gonzalez JP, Bowen MD, Nichol ST, Rico-Hesse R (July 1996). "Genetic characterization and phylogeny of Sabiá virus, an emergent pathogen in Brazil". Virology. 221 (2): 318–24. doi:10.1006/viro.1996.0381. PMID 8661442.
  22. ^ Emonet S, Lemasson JJ, Gonzalez JP, de Lamballerie X, Charrel RN (July 2006). "Phylogeny and evolution of old world arenaviruses". Virology. 350 (2): 251–7. doi:10.1016/j.virol.2006.01.026. PMID 16494913.
  23. ^ Gonzalez JP, Sanchez A, Rico-Hesse R (July 1995). "Molecular phylogeny of Guanarito virus, an emerging arenavirus affecting humans". The American Journal of Tropical Medicine and Hygiene. 53 (1): 1–6. doi:10.4269/ajtmh.1995.53.1. PMID 7542842.
  24. ^ Gonzalez JP, Du Saussay C, Gautun JC, McCormick JB, Mouchet J (1985). "[Dengue in Burkina Faso (ex-Upper Volta): seasonal epidemics in the urban area of Ouagadougou]". Bulletin de la Société de Pathologie Exotique et de ses Filiales. 78 (1): 7–14. PMID 3886182.
  25. ^ Barbazan P, Yoksan S, Gonzalez JP (June 2002). "Dengue hemorrhagic fever epidemiology in Thailand: description and forecasting of epidemics". Microbes and Infection. 4 (7): 699–705. doi:10.1016/S1286-4579(02)01589-7. PMID 12067829.
  26. ^ Gonzalez JP, Josse R, Johnson ED, Merlin M, Georges AJ, Abandja J, Danyod M, Delaporte E, Dupont A, Ghogomu A (July 1989). "Antibody prevalence against haemorrhagic fever viruses in randomized representative Central African populations". Research in Virology. 140 (4): 319–31. doi:10.1016/S0923-2516(89)80112-8. PMID 2505350.
  27. ^ Johnson ED, Gonzalez JP, Georges A (September 1993). "Haemorrhagic fever virus activity in equatorial Africa: distribution and prevalence of filovirus reactive antibody in the Central African Republic". Transactions of the Royal Society of Tropical Medicine and Hygiene. 87 (5): 530–5. doi:10.1016/0035-9203(93)90075-2. PMID 8266402.
  28. ^ Gonzalez JP, Wauquier N, Vincent T (February 2018). "Revisiting Ebola, a quiet river in the heart of Africa". Médecine et Santé Tropicales. 28 (1): 12–17. doi:10.1684/mst.2018.0751. PMID 29616631.
  29. ^ Gonzalez JP, Herbreteau V, Morvan J, Leroy EM (September 2005). "Ebola virus circulation in Africa: a balance between clinical expression and epidemiological silence". Bulletin de la Société de Pathologie Exotique. 98 (3): 210–7. PMID 16267963.
  30. ^ Wauquier N, Bangura J, Moses L, Humarr Khan S, Coomber M, Lungay V, Gbakie M, Sesay MS, Gassama IA, Massally JL, Gbakima A, Squire J, Lamin M, Kanneh L, Yillah M, Kargbo K, Roberts W, Vandi M, Kargbo D, Vincent T, Jambai A, Guttieri M, Fair J, Souris M, Gonzalez JP (April 2015). "Understanding the emergence of ebola virus disease in sierra leone: stalking the virus in the threatening wake of emergence". PLOS Currents. 7. doi:10.1371/currents.outbreaks.9a6530ab7bb9096b34143230ab01cdef. PMC 4423925. PMID 25969797.
  31. ^ "The Ebola Footprint – Broader Than You Think". www.oneillinstituteblog.org. 2018-02-22. Retrieved 2018-06-29.
  32. ^ "The Truth About Ebola". Time. Retrieved 2018-06-29.
  33. ^ Gonzalez JP, Prugnolle F, Leroy E (2013). "Men, primates, and germs: an ongoing affair". One Health: The Human-Animal-Environment Interfaces in Emerging Infectious Diseases. Current Topics in Microbiology and Immunology. Vol. 365. pp. 337–53. doi:10.1007/82_2012_304. ISBN 978-3-642-36888-2. PMC 7121697. PMID 23239237.
  34. ^ Souris M, Selenic D, Khaklang S, Ninphanomchai S, Minet G, Gonzalez JP, Kittayapong P (January 2014). "Poultry farm vulnerability and risk of avian influenza re-emergence in Thailand". International Journal of Environmental Research and Public Health. 11 (1): 934–51. doi:10.3390/ijerph110100934. PMC 3924483. PMID 24413705.
  35. ^ Leroy E, Gonzalez JP (September 2012). "Filovirus research in Gabon and equatorial Africa: the experience of a research center in the heart of Africa". Viruses. 4 (9): 1592–604. doi:10.3390/v4091592. PMC 3499821. PMID 23170174.
  36. ^ Bourgarel M, Wauquier N, Gonzalez JP (2010-06-03). "Emerging viral threats in Gabon: health capacities and response to the risk of emerging zoonotic diseases in Central Africa". Emerging Health Threats Journal. 3: e7. doi:10.3402/ehtj.v3i0.7099. PMC 3167654. PMID 22460397.
  37. ^ Idiata DF, Gonzalez JP, Obiang LE (2010). 50 ans de recherche scientifique au Gabon: bilan et perspectives (in French). Éditions du CENAREST. ISBN 9782356650283.
  38. ^ "jpgonzalez@metabiota.com – PLOS Currents Outbreaks". PLOS Currents Outbreaks. ISSN 2157-3999.
  39. ^ "Jean-Paul GONZALEZ". ISHEID 2018. Retrieved 2018-06-29.
  40. ^ Luboya LW, Malangu M, Kaleka M, Ngulu N, Nkokele B, Maryabo K, Pourrut X, Vincent T, Gonzalez JP (April 2017). "An assessment of caprine tuberculosis prevalence in Lubumbashi slaughterhouse, Democratic Republic of Congo". Tropical Animal Health and Production. 49 (4): 875–878. doi:10.1007/s11250-017-1252-5. PMID 28258542. S2CID 29947263.
  41. ^ Yurchenko OO, Dubina DO, Vynograd NO, Gonzalez JP (August 2017). "Partial Characterization of Tick-Borne Encephalitis Virus Isolates from Ticks of Southern Ukraine". Vector Borne and Zoonotic Diseases. 17 (8): 550–557. doi:10.1089/vbz.2016.2094. PMC 5564047. PMID 28654319.
  42. ^ "Leadership and Staff". ceezad.org. Retrieved 2018-06-29.
  43. ^ "Kansas State University taking over production of One Health Newsletter, the go-to..." www.k-state.edu. Retrieved 2018-06-29.
  44. ^ "One Health Initiative - One World One Medicine One Health". www.onehealthinitiative.com. Retrieved 2018-06-29.
  45. ^ Ezama A, Gonzalez JP, Majalija S, Bajunirwe F (March 2018). "Assessing short evolution brucellosis in a highly brucella endemic cattle keeping population of Western Uganda: a complementary use of Rose Bengal test and IgM rapid diagnostic test". BMC Public Health. 18 (1): 315. doi:10.1186/s12889-018-5228-9. PMC 5838946. PMID 29506522.
  46. ^ "International sickle cell symposium gets underway". www.newvision.co.ug. Retrieved 2018-06-29.
  47. ^ "My Bibliography - My NCBI Collection". www.ncbi.nlm.nih.gov. Retrieved 2018-05-23.
  48. ^ "Vie et Mort des Epidemies". 2015.
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